ENZO Gut Repair
Australasian Integrative Medicine Conference 2016 - Presentation:
Importance of Gut HealthThe health of our gut is critically important for our mental, and physical well-being. Nutritional science has shown how our food, and particularly the plant-nutrients in our food, contribute to the health of our gut walls, and maintain the beneficial populations of the many different types of gut bacteria that we live with in a symbiotic relationship.
The Specific Actives in ENZO Gut RepairThe specific combination of the plant-polyphenol compounds in ENZO Gut Repair make the formulation an exceptionally useful aid in achieving and maintaining a healthy gut. It is the combination of the different types of plant compounds that makes ENZO Gut Repair such an extraordinary formulation. Each polyphenol compound has a different molecular configuration that contributes a different range of activities working on different factors in the gut, calming irritation and improving health. Hence, the combination of plant compounds in ENZO Gut Repair delivers an effective broad spectrum of health benefits to the gut.
Enzogenol® - New Zealand pine bark extract contains 80% proanthocyanidins that have strong anti-oxidant and natural anti-inflammatory properties that lead to reduced oxidative stress and irritation of the gut walls. Proanthocyanidins also act as pre-biotics which means that they promote a healthy gut flora, particularly by reducing the growth of unwanted, harmful types of bacteria in the gut.
TeaHeathyTM, Green tea extract from the fresh leaves of Camellia sinensis contains 50% EGCG, and a range of other healthy green tea polyphenols with exceptional anti-oxidant and natural anti-inflammatory properties. EGCG is a very potent health promoting polyphenol that has been studied extensively and is a key contributor to the health benefits of green tea.
POMx® , Pomegranate extract is a highly concentrated extract from Californian pomegranate fruit, and contains 40% punicalagins and elagic acid. These are special pomegranate polyphenols that are highly effective in supporting a healthy gut free of irritation.
Novasoy®, Soybean extract is a very high quality, Non-GMO, extract made from soy beans. It contains the soy isoflavones Genistein, Daidzein and Glycitein that support gut health. The higher consumption of these soy bean polyphenols is part of the reason that very few people in Asian countries suffer from bowel irritations.
Below is a selection of the research evidence that has shown how the particular plant polyphenols present in ENZO Gut Repair can affect gut inflammation, barrier function and microflora. (Full research papers available from ENZO Nutraceuticals Ltd)
Catechin, one of the main polyphenols in Enzogenol and in TeaHealthy, has been shown to reduce damage to the gut walls caused by inflammation. In a rat model of chemically induced ulcerative colitis catechin feeding led to a significant decrease in colon damage (Sato).
Research on Elagic Acid and Gut Health
Pomegranate (Punica granatum L.) has traditionally been used for the treatment of various inflammatory diseases, including ulcerative colitis. Because its extract, POMx, is rich in ellagitannins, which release ellagic acid when hydrolyzed, consumption of POMx has several potential health effects, including prevention of inflammatory diseases. Research in a chemically induced ulcerative colitis mouse model has shown how elagic acid can reduce inflammation and inhibit disease progression. In acute UC, ellagic acid ameliorates disease severity through the profile of inflammatory mediators (IL-6, TNF-α, and IFN-γ). In the chronic UC, ellagic acid inhibits the progression of the disease, reducing intestinal inflammation and decreasing histological scores. Moreover, mediators such as COX-2 and iNOS are downregulated and the signaling pathways p38 MAPK, NF-κB, and STAT3 are blocked (Marin).
Research on the Effects of Polyphenols on the Gut Microflora
EGCG, catechin, PACs, and the other phenolic components of TeaHealthy and Enzogenol influence the growth and metabolism of the many different types of bacteria in our gut. Different strains of intestinal bacteria have varying degrees of growth sensitivity to these phenolic compounds and their metabolites. Growth of certain pathogenic bacteria (Clostridium perfringens, C. difficile and Bacteroides species) can be inhibited, while commensal anaerobes like Bifidobacteria and Lactobacilli are not inhibited and can proliferate significantly. In a study on postmenopausal women supplementation with Isoflavones, genistein, diazein, glycetein from soy, there was an increase in Bifidobacteria within 2 months without using any actual pro-biotics. In this trial, the isoflavones altered dominant bacterial communities with increases in Clostridium coccoides−Eubacterium rectale (Erec) cluster, Faecalibacterium prasnutzii subgroup, and Lactobacillus−Enterococcus group. This research demonstrates how these compounds change the intestinal environment in a positive way and modulate the intestinal bacterial populations, by acting as metabolic prebiotics. This bioactivity plays an important role in the maintenance of gastrointestinal health (Lee, Tzounis, Etxeberria).
Song P. et al., 2011, Dietary Grape-Seed Procyanidins Decreased Postweaning Diarrhea by Modulating Intestinal Permeability and Suppressing Oxidative Stress in Rats, J. Agric. Food Chem. 59:p6227
Kim YH. et al., 2008. Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis. International Immunopharmacology 8:p1698
Mochizuki M1, Hasegawa N. 2004. Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Phytother Res. 18(12):p1027
Sergent T. et al., 2010, Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chemico-Biological Interactions 188:p659
Na HK., Surh YJ., 2006, Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate. Mol Nutr Food Res. 50(2):p152
Sato K. et al., 1998, Dietary supplementation of catechins and alpha-tocopherol accelerates the healing of trinitrobenzene sulfonic acid-induced ulcerative colitis in rats. J Nutr Sci Vitaminol 44(6):p769
Marín M. 2013. Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis. J Ethnopharmacol. 150(3):p925
Lee HC. et al., 2006, Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res Microbiol. 157(9):p876
Tzounis X. et al., 2011, Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr. 93(1):p62
Etxeberria U. et al., 2013. Impact of Polyphenols and Polyphenol-Rich Dietary Sources on Gut Microbiota Composition. J. Agric. Food Chem. 61:p9517