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ENZO Gut Repair

Australasian Integrative Medicine Conference 2016 - Presentation:

Effects of Flavonoids on and in the Gut:

  • Microflora
    • modulating intestinal bacterial population
  • Gut Inflammation
    • modulating inflammatory cascades
  • Barrier Function
    • modulating tight junction proteins and mucus
Sunday 10 April 2016
Matt talking at AIMA conference April 2016-971
(Download full presentation pdf here)
 

ENZO-Gut-Repair-(KF) 223h

ENZO Gut Repair is specifically formulated to support gut health based on the latest scientific research.

ENZO Gut Repair is an entirely natural plant-based product that combines specific plant extracts from pine bark, green tea, soy beans and pomegranate which all promote a healthy gut. The formulation delivers effective dose levels of the extracts and their active compounds. Two capsules daily supply the appropriate and effective amount of the active plant compounds to balance your gut environment to a healthy state devoid of irritation, and able to effectively digest and absorb the nutrients in your food.

Human-GutImportance of Gut Health

The health of our gut is critically important for our mental, and physical well-being. Nutritional science has shown how our food, and particularly the plant-nutrients in our food, contribute to the health of our gut walls, and maintain the beneficial populations of the many different types of gut bacteria that we live with in a symbiotic relationship.

The Specific Actives in ENZO Gut Repair

The specific combination of the plant-polyphenol compounds in ENZO Gut Repair make the formulation an exceptionally useful aid in achieving and maintaining a healthy gut. It is the combination of the different types of plant compounds that makes ENZO Gut Repair such an extraordinary formulation. Each polyphenol compound has a different molecular configuration that contributes a different range of activities working on different factors in the gut, calming irritation and improving health. Hence, the combination of plant compounds in ENZO Gut Repair delivers an effective broad spectrum of health benefits to the gut.
Bark-chipsEnzogenol® - New Zealand pine bark extract contains 80% proanthocyanidins that have strong anti-oxidant and natural anti-inflammatory properties that lead to reduced oxidative stress and irritation of the gut walls. Proanthocyanidins also act as pre-biotics which means that they promote a healthy gut flora, particularly by reducing the growth of unwanted, harmful types of bacteria in the gut.


greentea01TeaHeathyTM, Green tea extract from the fresh leaves of Camellia sinensis contains 50% EGCG, and a range of other healthy green tea polyphenols with exceptional anti-oxidant and natural anti-inflammatory properties. EGCG is a very potent health promoting polyphenol that has been studied extensively and is a key contributor to the health benefits of green tea.


Pomegranate01POMx® , Pomegranate extract is a highly concentrated extract from Californian pomegranate fruit, and contains 40% punicalagins and elagic acid. These are special pomegranate polyphenols that are highly effective in supporting a healthy gut free of irritation.



soybeans01Novasoy®, Soybean extract is a very high quality, Non-GMO, extract made from soy beans. It contains the soy isoflavones Genistein, Daidzein and Glycitein that support gut health. The higher consumption of these soy bean polyphenols is part of the reason that very few people in Asian countries suffer from bowel irritations.

Research Science

Below is a selection of the research evidence that has shown how the particular plant polyphenols present in ENZO Gut Repair can affect gut inflammation, barrier function and microflora. (Full research papers available from ENZO Nutraceuticals Ltd)

Polyphenols-in-treatment-of-IBDPolyphenols are phytochemicals that are abundant in plant foods. Increased intake of polyphenols promotes the health of many organ systems in our body. The health benefits for the gut occur through the anti-inflammatory properties of the polyphenols which make these plant compounds a very important part of our diet. They can modulate the inflammatory response by getting into direct contact with the cells in our gut walls and changing their responses to several key factors controlling inflammation.Dietary-Polyphenols-modulate-intestinal-inflammatory-response

ENZO Gut Repair compounds can inhibit the response to several pro-inflammatory factors (in the NFκB and MAPK pathways) that are produced within our gut walls if we have an irritated bowel and consequently support lesser irritation and a re-balancing process in the gut. If the gut is not irritated ENZO Gut Repair will help to maintain gut heath and promote overall digestive health.

Research on Proanthocyanidins (PACs) and Piceatannol on Gut Health
PACs, which are the main polyphenol in Enzogenol, can increase the production of intestinal mucosal tight junction proteins in a rat model of postweaning diarrhea (Song). These are proteins responsible for the barrier function in the gut epithelium. In addition, this study also showed that PACs can also improve the anti-oxidant status of the gut epithelium (Song).
Piceatannol is a stilbene compound found in Enzogenol. It modifies multiple cellular targets by exerting immunosuppressive and antitumorigenic activities. In a mouse model of chemically induced colitis Piceatannol has been shown to slow down the development of colitis (Kim).
Pine bark extract has been shown to reduce mucosal damage in the gut in a rat model of chemically induced IBD (Mochizuki).

Research on Epigallocatechin-gallate (EGCG) and Gut Health
EGCG, the main polyphenol in TeaHealthy, can downregulate the inflammatory response in inflamed epithelial cells of the gut. EGCG has been shown to inhibit many of the inflammatory reactions that are involved in irritation and inflammation of the gut. EGCG significantly reduces the amount pro-inflammatory cytokines IL-6 and IL-8 produced by the gut, and by the immune cells. IL-6 stimulates the inflammatory and auto-immune reactions in the gut walls. IL-8 attracts neutrophils to the site of the gut irritation and promotes phagocytosis. EGCG downregulates the inflammatory response in inflamed intestinal epithelial cells by reducing pro-inflammatory cytokines IL-6 and IL-8 by 50-60% (Sergent).

The consumption of green tea has also been associated with lower rates of several cancers including bowel cancer, because EGCG can block each stage of cancer development by modulating signal transduction pathways involved in cell proliferation, transformation, inflammation, apoptosis, metastasis and invasion (Na).

Research on Catechin and Gut Health
Catechin, one of the main polyphenols in Enzogenol and in TeaHealthy, has been shown to reduce damage to the gut walls caused by inflammation. In a rat model of chemically induced ulcerative colitis catechin feeding led to a significant decrease in colon damage (Sato).

Research on Elagic Acid and Gut Health
Pomegranate (Punica granatum L.) has traditionally been used for the treatment of various inflammatory diseases, including ulcerative colitis. Because its extract, POMx, is rich in ellagitannins, which release ellagic acid when hydrolyzed, consumption of POMx has several potential health effects, including prevention of inflammatory diseases. Research in a chemically induced ulcerative colitis mouse model has shown how elagic acid can reduce inflammation and inhibit disease progression. In acute UC, ellagic acid ameliorates disease severity through the profile of inflammatory mediators (IL-6, TNF-α, and IFN-γ). In the chronic UC, ellagic acid inhibits the progression of the disease, reducing intestinal inflammation and decreasing histological scores. Moreover, mediators such as COX-2 and iNOS are downregulated and the signaling pathways p38 MAPK, NF-κB, and STAT3 are blocked (Marin).

Research on the Effects of Polyphenols on the Gut Microflora
EGCG, catechin, PACs, and the other phenolic components of TeaHealthy and Enzogenol influence the growth and metabolism of the many different types of bacteria in our gut. Different strains of intestinal bacteria have varying degrees of growth sensitivity to these phenolic compounds and their metabolites. Growth of certain pathogenic bacteria (Clostridium perfringens, C. difficile and Bacteroides species) can be inhibited, while commensal anaerobes like Bifidobacteria and Lactobacilli are not inhibited and can proliferate significantly. In a study on postmenopausal women supplementation with Isoflavones, genistein, diazein, glycetein from soy, there was an increase in Bifidobacteria within 2 months without using any actual pro-biotics. In this trial, the isoflavones altered dominant bacterial communities with increases in Clostridium coccoides−Eubacterium rectale (Erec) cluster, Faecalibacterium prasnutzii subgroup, and Lactobacillus−Enterococcus group.  This research demonstrates how these compounds change the intestinal environment in a positive way and modulate the intestinal bacterial populations, by acting as metabolic prebiotics. This bioactivity plays an important role in the maintenance of gastrointestinal health (Lee, Tzounis, Etxeberria).

References:

Song P. et al., 2011, Dietary Grape-Seed Procyanidins Decreased Postweaning Diarrhea by Modulating Intestinal Permeability and Suppressing Oxidative Stress in Rats, J. Agric. Food Chem. 59:p6227

Kim YH. et al., 2008. Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis. International Immunopharmacology 8:p1698

Mochizuki M1, Hasegawa N. 2004. Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Phytother Res. 18(12):p1027

Sergent T. et al., 2010, Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chemico-Biological Interactions 188:p659

Na HK., Surh YJ., 2006, Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate. Mol Nutr Food Res. 50(2):p152

Sato K. et al., 1998, Dietary supplementation of catechins and alpha-tocopherol accelerates the healing of trinitrobenzene sulfonic acid-induced ulcerative colitis in rats. J Nutr Sci Vitaminol 44(6):p769

Marín M. 2013. Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis. J Ethnopharmacol. 150(3):p925

Lee HC. et al., 2006, Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res Microbiol. 157(9):p876

Tzounis X. et al., 2011, Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr. 93(1):p62

Etxeberria U. et al., 2013. Impact of Polyphenols and Polyphenol-Rich Dietary Sources on Gut Microbiota Composition. J. Agric. Food Chem. 61:p9517